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The glucagon-like peptide-1 receptor agonists (GLP-1RAs) have important beneficial effects on glycemic control and body weight along with their pleiotropic effects on various systems of the body. However, until now these agents were administered via an injection posing a challenge to patient convenience. Oral semaglutide is a first in class oral GLP-1RA co-formulated with an absorption enhancer for the treatment of type 2 diabetes mellitus (T2DM). The clinical efficacy and safety of oral semaglutide has been extensively evaluated in the Peptide InnOvatioN for Early diabEtes tReatment (PIONEER) program of clinical trials. This review shall elaborate on the unique diabetes situation in India and why the oral GLP-1RA (semaglutide) will be a game-changer in the Indian setting
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Background: Anemia is a global health problem affecting mostly in developing countries. Iron deficiency anemia is a significant health problem and especially in developing countries. It’s the most neglected micronutrient deficiency disorder among under-five children. The objective of the study was to assess the prevalence and determinants of anemia among under-five children and to suggest suitable remediable measures to prevent and control of anemia.Method: This is a cross-sectional study. Household survey carried out in twelve villages in a rural practice area Dhaura, Bareilly. A total of 396 children were contacted for obtaining blood samples by taking 33 children from each village. Blood samples were taken from all children between the 6th month to 59 months of age using simple random sampling. After the collection, data will be analyzed using the SPSS software version 20.Result: A total of 47.5% of the children were found to have anemia. Among them 25.5% had mild, 63.3% had moderate and 11.2% had severe anemia. The majority of them were male 269 (67.9%). The mean age of participating children was 17.351±7.785 months. 48.2% of anemic children were low birth weight.Conclusion: High prevalence could be due to deficiency in iron nutrition among under-five children associated with poor food availability, due to lack of nutritional education and other sociodemographic conditions, child’s age and worse household conditions also contributed to the prevalence of anemia.
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Background: Needles are one of the biomedical waste materials generated during the treatment or procedure in the hospital. Improper handling, capping or disposal technique causes a major health hazard among the health care workers (HCWs). Needle stick injuries (NSIs) can occur accidentally at any time when people use, disassemble, or dispose needle. The aim of the present study were to find out the burden of chronic morbid condition due to NSIs to HCWs, to find out various risk factors responsible for causing chronic disease to HCWs and to suggest the prevention and control of needle stick injury among the HCWs.Methods: A cross-sectional study, conducted among HCWs. Sample size was estimated by using standard formula and 312 HCWs were taken in study. Equal number of respondent was taken from each group. The information has been collected and data entry has been done using specific software SPSS version 20.0.Results: Most of the HCWs were infected with hepatitis B (24.0%) followed by hepatitis C virus (8.7%) and HIV (1.9%) after the percutaneous injuries with needle of infectious patients during any intervention procedures of the patients.Conclusions: Occupational exposures to percutaneous injuries are substantial source of infections with blood borne pathogens among health-care workers because of the poor practice as well as not opting personal protective equipment’s during intervention process regarding preventive and control measures. These infections are highly preventable and should be eliminated.
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Background: Microvascular complications of Type 2 Diabetes Mellitus (T2DM), (retinopathy and nephropathy) have a similar etiopathogenetic mechanism besides genetic predisposition. Even though these two complications frequently co-exist, their frequency varies. The association of these two significant complications and their co-existence needs a relook.Methods: Four hundred patients suffering from type 2 DM visiting a tertiary care hospital in Western India were included in this cross-sectional study. Of these, 200 patients were of Diabetic Nephropathy (DN) and 200 were without DN. The presence of albuminuria (urine albumin-creatinine ratio) was used to detect diabetic nephropathy. Fundoscopy was performed in all patients to look for Diabetic Retinopathy (DR).Results: In this study, 77.5% patients with DN had retinopathy, while in patients without DN, only 52% patients had retinopathy. This was a statistically significant finding. (p value <0.001). The distribution of types of retinopathy in patients with DN was 63.0% Non-Proliferative Diabetic Retinopathy (NPDR), 12.5% Proliferative Diabetic Retinopathy (PDR) and 2% Clinically Significant Macular Edema (CSME). While in those without DN, 50.5% had NPDR, 1.5% had PDR and none had macular edema.Conclusions: Microalbuminuria, which has been used so far to diagnose DN, may be considered as a reliable predicter of diabetic retinopathy in type 2 diabetes mellitus patients. This simple marker can help screen all patients with Diabetes for nephropathy and retinopathy both and should take place at the first visit/ contact of the healthcare personnel. This can help prevent microvascular complications early and help in goal directed therapy.
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Background: HIV/AIDS is such a dreaded disease which can be prevented if the people are aware of the ways to do so. Urban slums share a specific position in the demographic profile of district because of the inequalities of health care system where the rural health care system is far to reach and the more flourished private health care system is unaffordable for most of the inhabitants. HIV/AIDS is not only a health-related problem but it also has socioeconomic, behavioral and cultural aspects. Methods: Descriptive cross-sectional among currently married women in reproductive age group (15-49 years) residing in any of the selected urban slums of district Gorakhpur. Cluster sampling was used and clusters were chosen by probability proportional to size (PPS) method of cluster sampling from a list of urban slums obtained from District Urban Development Authority (DUDA), Gorakhpur. The final sample size was 600. Results: 82% of women had ever heard about HIV/AIDS and 72% of women got the knowledge about HIV through television followed by 56% of woman who got knowledge by relatives and friends. 68% of woman believes that the mode of transmission of HIV is unsafe sex followed by 58% of women who believed that infected blood transfusion is the mode of transmission of HIV. Conclusions: Awareness is crucial in the prevention and control of HIV/AIDS. Women should have more access to the knowledge resources and facilities for testing and prevention of HIV/AIDS.
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Background: Hand hygiene is a milestone in the field of infectious disease control. Promotion of improved hand hygiene has been recognized as an important public health measure. Therefore hand washing is being promoted in various ways. This study has been conducted to assess the level of knowledge and attitude regarding hand hygiene practices amongst the medical students to identify areas of gaps in their knowledge, attitude and practices.Methods: This is a cross sectional study conducted among medical undergraduates of a private medical college in western Utter Pradesh. A pre tested questionnaire with multiple choice questions was used for collection of data.Results: A total of 246 MBBS students participated in the study out of which 50.4 % students were male and rest were female. 78.5% participants were belonging to the age group 19-21 years. Students have good knowledge of hand washing irrespective of their educational front.Conclusions: The results of our study are fairly good still a proper training program is required to generate awareness among the community. Maintenance of hand hygiene should be a part of our education system at primary level.
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Background: India is one of the countries with highest number of diabetes patients. Patients of type 2 diabetes mellitus are usually dyslipidemic. The objective of the research was to study the pattern of dyslipidemia and to study the correlation of glycemic control with dyslipidemia in type 2 diabetes mellitus patients.Methods: A cross sectional observational study was performed on patients of type 2 diabetes mellitus over 6 months period. The study included 200 patients and the variables recorded were demographic profile, FBS, PPBS, HbA1C and lipid profile parameters. The patients were divided into 3 groups according to HbA1C level i.e. Group I (Good glycemic control HbA1C 6-7 gm%), group II (Fair glycemic control HbA1C 7.1-8.2 gm%) and group III (poor glycemic control, HbA1C >8.2 gm%).Results: The data showed that TG level was maximum in group III and was minimum in group I. Comparison between the group shows a significant difference between all the groups (P <0.001). A significant positive correlation (Correlation coefficient 0.67, P <0.001) was also observed between level of TG and HbA1C. Similarly, LDL level was also highest in group III with a significant difference with other two groups (P <0.05). Also, a positive correlation (Correlation coefficient 0.64, P <0.05) was observed between LDL and HbA1C. On the other hand, HDL was lowest in group III as compared to groups I and II (P <0.001) and a negative correlation (Correlation coefficient -0.716, P <0.001) was seen between HDL and HbA1C.Conclusions: Dyslipidemia is less prevalent in diabetics who have better glycemic control.
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Background: Needle stick injuries (NSIs) are a hazard for people who work with hypodermic syringes and other needle equipment. These injuries can occur at any time when people use, disassemble, or dispose of needles. Needle Stick and Sharps Injuries (NSSIs) are one of the major risk factors for blood-borne infections. The aim and objectives of the study were to assess the knowledge, attitude, practice and prevalence of NSIs among nurses in a private tertiary care hospital of district Bareilly; to recommended the preventive measure to control the injuries.Methods: A survey has been conducted in August 2013 to February 2014 among the nurses. This is a cross-sectional study. A purposive sampling was done aimed at covering at least 50 trained nurses and 50 nursing students working in a private tertiary care hospital Bareilly.Results: The prevalence of needle stick injuries per year equals 69.0%. Self inflicted were most common among nurses working in the wards. Instruments contaminated with infectious material accounted for the injuries in the study group of nurses.Conclusions: NSSIs are highly prevalent among nurses, and prevention is the most effective way to protect nurses from infectious diseases. The most common cause of injuries from needles was an improper handling of syringes and needles after injections.
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We report a 12-year-old boy with cavernomatous malformation of the portal vein who presented with repeated hematemesis. Inferior meso-caval shunt was performed to decompress the portal hypertension. There was minimal dissection and disturbance of periportal collateral channels in comparison to using the superior mesenteric vein. One year later, esophagoscopy showed no varices, and he has had no further episode of bleed.